DICYCLOMINE HYDROCHLORIDE
DICYCLOMINE HYDROCHLORIDE
CAS: 67-92-5
Molecular Formula: C19H36ClNO2
DICYCLOMINE HYDROCHLORIDE - Names and Identifiers
| Name | DICYCLOMINE HYDROCHLORIDE |
| Synonyms | Bentyl) DICYCLOMINE HCL LABOTEST-BB LT00771946 DICYCLOMINE HYDROCHLORIDE DICYCLOVERINE HCL (DICYCLOMINE HCL) [BICYCLOHEXYL]-1-CARBOXYLIC ACID DIETHYLAMINOETHYL ESTER HYDROCHLORIDE [2-[[[1,1'-bicyclohexyl]-1-ylcarbonyl]oxy]ethyl]diethylammonium chloride (1,1’-bicyclohexyl)-1-carboxylicacid,2-(diethylamino)ethylester,hydrochlo [1,1'-BICYCLOHEXYL]-1-CARBOXYLIC ACID 2-(DIETHYLAMINO) ETHYL ESTER, HYDROCHLORIDE |
| CAS | 67-92-5 |
| EINECS | 200-671-1 |
DICYCLOMINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C19H36ClNO2 |
| Molar Mass | 345.95 |
| Melting Point | 164-166°C |
| Solubility | H2O: 50mg/mL |
| Appearance | powder |
| Color | off-white |
| Storage Condition | -20°C Freezer |
DICYCLOMINE HYDROCHLORIDE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | DT7350000 |
| HS Code | 2922199695 |
| Toxicity | LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82 |
DICYCLOMINE HYDROCHLORIDE - References
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Dicyclomine hydrochloride is an effective oral active muscarinic cholinergic receptor (muscarinic cholinergic receptors) antagonist. Dicyclomine hydrochloride showed high affinity for both the M1 receptor subtype (Ki = 5.1 nM) and the M2 receptor subtype (Ki = 54.6 nM) in the brush margin membrane and the basal membrane. Dicyclomine hydrochloride is an antispasmodic agent that relieves gastrointestinal smooth muscle spasm in vivo. |
| target | Ki: 5.1 nM (muscarinic M1 receptor subtype in brush-border membrane)Ki: 54.6 nM (muscarinic M2 receptor subtype in basic plasma membrane |
| Animal Model: | C57Bl/6 mice |
| Dosage: | 2.0, 4.0, and 8.0 mg/kg |
| Administration: | Intraperitoneal injection; daily; 7 days |
| Result: | Produced impairments due to actions of the agent outside of the hippocampus. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 625 mg/kg; Oral-mouse LD50: 625 mg/kg |
| flammability hazard characteristics | flammability; Combustion produces toxic nitrogen oxides and hydrogen chloride smoke; Side effects of patient medication; Stiffness, dyspnea, paleness |
| storage and transportation characteristics | ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 02:00:26
